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目的探讨血清降钙素原(PCT)检测在急性加重期慢性阻塞性肺疾病(AECOPD)治疗中的应用价值。方法将收治的66例AECOPD患者随机分为观察组和对照组，观察组根据PCT检测结果指导抗生素使用，对照组由临床经验丰富医生指导抗生素使用，检测两组患者治疗前后血清PCT、和Hs-CRP及白细胞计数，同时对比两组抗生素使用时间、费用、住院天数、二重感染率及1年内AECOPD发生率。结果两组治疗后血清PCT、Hs-CRP含量及白细胞计数均低于治疗前(P0.05)。观察组抗生素使用时间、费用、住院时间、二重感染率及1年内AECOPD发生率均显著优于对照组，两组间差异有统计学意义(P<0.05)。结论血清PCT检测可为AECOPD患者临床使用抗生素提供指导，而合理使用抗生素对于提高治疗效果及减少复发均具有积极意义。“,”Objective To explore the significance of serum procalcitonin (PCT)in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD)and application value in the treatment.Methods 66 cases of AECOPD were randomly divided into the observation group and the control group,the observation group according to the results of PCT detection guide the antibiotic use,the control group used by clinical experienced doctor guidance of antibiotics,detection of serum PCT,Hs-CRP and white cel count before and after treatment in two groups of patients,and compared using two groups of antibiotics time,cost,hospitalization days,double infection rate and within 1 years the incidence rate of AECOPD.Results The two groups after treatment,Hs-CRP content and white blood cel count,serum PCT were obviously lower than those before therapy ( 0.05).The observation group antibiotic time,expenses,hospitalization time,double infection rate and within 1 years the incidence rate of AECOPD was significantly bet er than the control group,there was statistical y significant dif erence between the two groups ( <0.05).Conclusion The detection of serum PCT can provide guidance for the clinical use of antibiotics in patients with AECOPD,and the rational use of antibiotics to improve therapeutic ef ect and reduce the recurrence are of positive significance.