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目的 研究血清肝纤维化指标透明质酸 (HA)、Ⅳ型胶原 (ⅣC)及层粘蛋白 (LN)与慢性乙型肝炎肝纤维化的关系。方法 对 2 5 2例慢性乙型肝炎患者用放射免疫法检测血清HA、ⅣC、LN水平及定量PCR检测血清HBV -DNA。结果 血清HA、ⅣC、LN水平与慢性肝炎发展呈正相关 ,且在慢性重度肝炎及肝硬化阶段处于最高水平 (P <0 0 1)。结论 血清HA、ⅣC、LN水平可不同程度反映肝纤维化程度 ,可作为肝纤维化血清检测指标。
Objective To study the relationship between serum hyaluronic acid (HA), type Ⅳ collagen (ⅣC) and laminin (LN) in liver fibrosis and liver fibrosis in chronic hepatitis B patients. Methods Serum levels of HA, IVC and LN were measured by radioimmunoassay in 225 cases of chronic hepatitis B patients and serum HBV-DNA by quantitative PCR. Results Serum levels of HA, IVC and LN were positively correlated with the development of chronic hepatitis and were the highest in patients with chronic severe hepatitis and cirrhosis (P <0.01). Conclusions Serum levels of HA, IVC and LN may reflect the degree of liver fibrosis to varying degrees and may be used as the detection index of serum of liver fibrosis.