论文部分内容阅读
本文总结我院收治可供诊断分析的５８例小儿恶性淋巴瘤（ＭＬ），其中男４６例，女１２例，中位年龄６，６岁，霍奇金、氏淋巴瘤（ＨＬ）１７例，非霍奇金氏淋巴瘤（ＮＨＬ）４１例。在实验室方面，我们采用病理及细胞形态学检查的同时，抽取淋巴结或胸、腹腔穿刺液作组织化学染色检查，共５０例，以确定诊断及分型。三种组化是：ＡｇＮＯＲ染色一可鉴别系瘤细胞或非瘤细胞疾患，其灵敏度及特异性均较高。本组阳性率９６％。ＰＯＸ染色可初步分清瘤细胞属淋巴细胞秒或髓细胞系，本组均呈阴性反应，提示属淋巴细胞系。ＰＡＳ染色基本能提示淋巴系细胞的来源，尤其对ＮＨＬ之细胞表面标记可概略分型，若ＰＡＳ阴性，多属Ｂ淋巴细胞型占３２例），ＰＡＳ阳性，多属Ｔ淋巴细胞型（占１８例）。综上，我们认为组化染色是一简单、快速、安全且较为准确的检查方法，能起到早期诊断的作用。在分型方面：ＨＬＩ＋Ⅱ期占６５％，ＮＨ＋ＬⅡ＋Ⅳ期占８５％，说明小儿ＭＬ之病情多呈现急进而凶险。此外要十分重视与淋巴结炎、淋巴结核、白血病、神经母细胞瘤等疾患的鉴别。
This article summarizes the hospital for diagnosis and analysis of 58 cases of pediatric malignant lymphoma (ML), including 46 males and 12 females, median age 6,6 years old, Hodgkin’s lymphoma (HL) 17 cases, Non-Hodgkin’s lymphoma (NHL) in 41 cases. In the laboratory, we use pathological and morphological examination of the same time, extraction of lymph nodes or chest, peritoneal puncture fluid for histochemical staining, a total of 50 cases to determine the diagnosis and classification. The three histochemicals are: AgNOR staining can identify the Department of tumor cells or non-tumor cell disease, the sensitivity and specificity are high. The positive rate of 96% in this group. POX staining can be initially classified as lymphocytic lymphoma cells or myeloid cell line, this group were negative reactions, suggesting that is a lymphoid cell line. PAS staining can basically indicate the source of lymphoid cells, especially for NHL cell surface markers can be roughly sub-type, if PAS negative, mostly belong to B lymphocyte type accounted for 32 cases), PAS positive, mostly T lymphocyte type (18 example). In summary, we think that the histochemical staining is a simple, fast, safe and more accurate method of examination, can play an early role in diagnosis. In terms of typing: HLI + Ⅱ period accounted for 65%, NH + L Ⅱ + Ⅳ period accounted for 85%, indicating that many of the conditions in children with ML urgent and dangerous. In addition to pay great attention to and lymphadenitis, lymphoid tuberculosis, leukemia, neuroblastoma and other diseases identification.