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目的研究男性少精子症、无精子症与染色体核型及生殖激素关系。方法对177例少精、无精患者进行染色体核型分析和精液常规检测,采用电化学发光法测定血清LH、FSH、E2和T水平,并对其结果进行对比分析。结果染色体异常总数57例,染色体异常发生率为32.2%,性染色体异常27例占15%,常染色体异常30例占17%,男性无精子症的染色体异常发生率(50.8%)高于男性少精子症(23.3%),且差异有统计学意义。与染色体正常组比较,性染色体畸变组LH和FSH水平显著升高,T明显下降,常染色体畸变患者激素水平无明显差异;与精子密度正常组比较,无精子症组FSH、LH明显升高,少弱精子组患者激素水平无明显差异。结论染色体异常是造成男性不育重要因素,生殖激素水平变化与性染色体异常、精子密度减低有一定的相关性,激素测定对睾丸生精功能的判断有指导意义。
Objective To study the relationship between oligozoospermia, azoospermia and chromosomal karyotype and reproductive hormone in males. Methods A total of 177 cases of oligospermia and azoospermia were examined by karyotype analysis and routine semen examination. The serum levels of LH, FSH, E2 and T were measured by electrochemiluminescence. The results were compared with each other. Results There were 57 cases of chromosomal abnormalities, 32.2% of chromosomal abnormalities, 27 cases of sex chromosome abnormalities, 15 cases of autosomal abnormalities, and 30 cases of autosomal abnormalities. The incidence of chromosomal abnormalities (50.8%) in men with azoospermia was higher than that in men Sperm disease (23.3%), and the difference was statistically significant. Compared with the normal group, LH and FSH levels in sex chromosome aberration group were significantly increased, T decreased significantly, and there was no significant difference in the level of hormones in patients with autosomal aberration. Compared with normal group, FSH and LH in azoospermia group were significantly increased, Slightly weak sperm group patients hormone levels no significant difference. Conclusions Chromosomal abnormalities are the important factors causing male infertility. The changes of reproductive hormones are related to sex chromosome abnormalities and sperm densities. The determination of hormones has instructive significance for the testicular spermatogenesis.