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采用体外和体内实验以酒精诱导大鼠肝脏脂质过氧化为模型，研究了（Ｎａ＿２ＳｅＯ＿３）和锗（羧乙基锗倍半氧化物，Ｇｅ－１３２）联合应用的协同抗氧化作用。结果表明，酒精在体外和体内均可导致大鼠肝脏脂质过氧化。体外研究发现将硒和锗同时使用时（Ｎａ＿２ＳｅＯ＿３，２０μｍｏｌ／Ｌ＋Ｇｅ－１３２，１０．５ｍｍｏｌ／Ｌ），表现出比使用相同剂量单一的硒Ｎａ＿２ＳｅＯ＿３，２０μｍｏｌ／Ｌ）或锗（Ｇｅ－１３２，１０．５ｍｍｏｌ／Ｌ）具有更强的抗氧化作用。体内研究将硒和锗剂量减半同时使用（Ｎａ＿２ＳｅＯ＿３，０．０５５ｍｇ／ｋｇ＋Ｇｅ－１３２，１００ｍｇ／ｋｇ），具有类似如单一的较高剂量硒（Ｎａ＿２ＳｅＯ＿３，０．１１ｍｇ／ｋｇ）的抗氧化作用和比使用单一的较高剂量锗（Ｇｅ－１３２，２００ｍｇ／ｋｇ）更强的抗氧化作用。本次研究结果表明硒（Ｎａ＿２ＳｅＯ＿３）和锗（Ｇｅ－１３２）在体外及体内均具有协同抗氧化作用。
In vitro and in vivo experiments using alcohol-induced rat liver lipid peroxidation model to study the synergistic antioxidant effect of (Na2SeO_3) and germanium (carboxyethyl germanium sesquioxide, Ge-132) in combination. The results show that alcohol can lead to lipid peroxidation in rat liver both in vitro and in vivo. In vitro studies showed that when selenium and germanium were used simultaneously (Na 2 SeO 3, 20 μmol / L + Ge-132 and 10.5 mmol / L), selenium was more stable than Ge 2 O 3 5mmol / L) has a stronger antioxidant effect. In vivo studies of anti-oxidant effects such as single higher doses of selenium (Na 2 SeO 3, 0.11 mg / kg) and a combination of half-dose of selenium and germanium (Na 2 SeO 3,0.055 mg / kg + Ge-132,100 mg / kg) Greater antioxidant activity than using a single higher dose germanium (Ge-132, 200 mg / kg). The results of this study indicate that both selenium (Na 2 SeO 3) and germanium (Ge-132) have a synergistic antioxidant effect both in vitro and in vivo.