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目的研究ｒＣＮ十ＣＬＳ局部应用对减少高压电损伤组织进行性坏死的作用；方法使用该实验室已建立的重度高压电损伤模型新西兰大白兔４５只均分５组，治疗分别使用ｒＧＨ＋ＣＬＳ（１组），ＣＬＳ（２组），ｒＧＨ（３组），盐水（４组）和５组对照．临床解剖探查、组织学和超微结构等方法观察结果治疗１组有明显的减少组织坏死作用，１５ｄ动物伤肢完整而 ２，３和４组虽也各有不同程度延缓坏死的作用，但动物伤肢最终坏死丧失．５组７ｄ大部软组织基本坏死，１２ｄ坏死离断光电镜检查１组５ｄ，治疗后粒细胞浸润较少，炎性反应轻，有纤维组织细胞再生和新生的线粒体，１０ｄ修复过程明显，２，３，４组７ｄ后坏死明显，５组肌坏死迅速结论 ＣＬＳ持续组织内透析冲洗和 ｒＧＨ局部肌注能有效地减少电损伤组织坏死速度和范围，值得研究应用。
Objective To investigate the effect of local application of rCN-10 CLS on reducing necrosis of high-voltage injury tissue.Methods Forty-five New Zealand white rabbits were divided into five groups according to the established model of severe high-voltage electric injury in our laboratory. Group), CLS (group 2), rGH (group 3), saline (group 4) and control. Clinical anatomy, histology and ultrastructural observation of the results of treatment group 1 significantly reduce the role of tissue necrosis, 15d animals complete injury of the limbs 2,3 and 4 groups, although also have varying degrees of delay in the role of necrosis, but animals The final necrosis of the injured limb is lost. 5 days after operation, most of the soft tissue in the 7th day was basically necrotic, 12 days necrosis was examined by light microscopy for 1 day and 5 days. The granulocytes infiltrated less, the inflammatory reaction was lighter, the regenerated fibroblasts and mitochondria were regenerated, After 3 and 7 days, necrosis was obvious in group 3 and 4, and muscle necrosis in 5 groups was rapid. CONCLUSION: Continuous dialysis and rGH intramuscular injection of CLS can effectively reduce the rate and range of necrosis of electrical injury, which deserves to be studied and applied.