羧乙基锗倍半氧化物(Ge—132)能促进培养乳鼠心肌细胞DNA和RNA的合成,提高超氧化物歧化酶(SOD)的活性,维持细胞膜结构的稳定。异丙基肾上腺素可使心肌细胞乳酸脱氢酶(LDH)释放增加,细胞搏动停止,超微结构显示肌膜和线粒体严重受损。Ge—132可显著减少异两基肾上腺素引起心肌细胞释放LDH,维持细胞的搏动功能和超微结构的完整。 Carboxyethylgermanium sesquioxide (Ge-132) can promote the synthesis of DNA and RNA in cultured neonatal cardiomyocytes, increase the activity of superoxide dismutase (SOD), and maintain the stability of cell membrane structure. Isoproterenol can increase the release of lactate dehydrogenase (LDH) from cardiac myocytes, stop the beating of cells, and show ultrastructural damage to sarcolemma and mitochondria. Ge-132 can significantly reduce the release of LDH from cardiomyocytes induced by iso-adrenergic epinephrine, and maintain the pulsatile function and ultrastructural integrity of cells.