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目的比较胰岛素泵持续皮下输注速效胰岛素类似物(赖脯胰岛素,优泌乐)和短效人胰岛素(优泌林R)治疗新诊断的2型糖尿病的疗效差异。方法 86例住院需胰岛素治疗的新诊断2型糖尿病患者,随机分为两组:优泌乐组和优泌林R组,胰岛素泵治疗2周,比较两组患者治疗过程中每日3餐前后和睡前血糖、血糖达标时间、胰岛素量、低血糖发生率及胰岛素泵相关的副作用。结果优泌林R组和优泌乐组空腹血糖达标时间分别为(5.77±1.41)d和(3.17±1.36)d(P<0.01),餐后血糖达标时间分别为(8.64±2.39)d及(5.07±1.47)d(P<0.01);2周后3餐前和睡前血糖下降两组间差异无统计学意义(P>0.05);餐后血糖控制情况,优泌乐组优于优泌林R组(P<0.05),优泌乐组胰岛素用量较少,但差异无统计学意义。优泌乐组低血糖发生率低于优泌林R组(P<0.05)。结论胰岛素泵输注优泌乐及优泌林R均能使新诊断的2型糖尿病患者血糖得到良好控制,但优泌乐对餐后血糖控制更理想,血糖达标时所需时间更短,低血糖发生率更低。
Objective To compare the efficacy of continuous subcutaneous insulin infusion with insulin analogues (insulin lispro, etrylium) and short-acting human insulin (uriclin R) in the treatment of newly diagnosed type 2 diabetes mellitus. Methods A total of 86 patients with newly diagnosed type 2 diabetes requiring insulin therapy were randomly divided into two groups: Yubilee group and Yoululin R group, insulin pump for 2 weeks. The patients in the two groups were compared before and after 3 meals daily And bedtime blood sugar, blood glucose compliance time, the amount of insulin, the incidence of hypoglycemia and insulin pump-related side effects. Results The compliance time of fasting blood glucose in group Euurine R and group Yusu Le was (5.77 ± 1.41) d and (3.17 ± 1.36) d respectively (P <0.01), and the postprandial blood glucose time was (8.64 ± 2.39) d and (5.07 ± 1.47) d (P <0.01). There was no significant difference between the two groups before and after going to sleep in two weeks (P> 0.05). The postprandial glycemic control was superior to that R group (P <0.05), Yueshile group had less insulin dosage, but the difference was not statistically significant. The rate of hypoglycemia in You Se Lele group was lower than that in Youceng Lin R group (P <0.05). Conclusions Insulin pump infusion of Yubulie and Yoululin R can make the newly diagnosed patients with type 2 diabetes have a good control of blood glucose, but Uehara music is more ideal for postprandial blood glucose control, blood glucose compliance time is shorter, low Lower blood sugar.