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作者于1961年曾在“美国医学杂志”上报告用醋酸和丙二醇(Propylene Qlycol)化合后所生成的酯来治疗外耳道炎。该制剂系外用,酸硷值为pH3,有吸水性,能立即杀死细菌和霉菌,表面张力很低,容易扩散到外耳道每一角落。作者报告了300例,效果甚为满意,用药4～5天内炎症均完全消退。当时所选择的病例只有单纯的外耳道炎,不包括伴有湿疹样皮炎或皮脂溢性皮炎的病例。考虑到氢可地松对这些炎性病变应该有效,故将上述制剂内加入了氢可地松。
In 1961, the author reported in the Journal of the American Medical Journal the treatment of otitis externa with esters formed following the combination of Propylene Qlycol and acetic acid. The formulation is external use, pH value of pH3, a water absorption, can immediately kill bacteria and molds, the surface tension is very low, easy to spread to every corner of the external auditory canal. The authors reported 300 cases, the effect is very satisfactory, the medication within 4 to 5 days were completely subsided inflammation. The only cases selected at the time were pure otitis externa, excluding those associated with eczematous or seborrheic dermatitis. Taking into account the hydrocortisone on these inflammatory lesions should be effective, it will be added to the preparation of hydrocortisone.