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作者报道了自1973年5月起RTOP(放射治疗肿瘤组)对晚期头颈癌术前与术后放疗Ⅲ期临床研究长期随访结果。研究对象为口腔、口咽、下咽及声门上T_(3-4),N_(0-2)期未经治疗的可手术原发鳞癌277例。随机分组为术前放疗组136例,术后放疗组141例。术前放疗组先给常规分割外照射5000cGy/5～5.5周,放疗后4～6周手术;术后放疗组先行手术,术后4周行常规分割外照射6000cGy/6～7周。两组手术方式及切除范围相同。研究的终点是区域-局部控制率、存活率、死亡原因及治疗合并症。全组病人随访7～15年。在放疗后头2年内主要死亡原因为区域-局部失败。两
The authors reported on the long-term follow-up results of a phase III clinical study of preoperative and postoperative radiotherapy for advanced head and neck cancer since May 1973 in the RTOP group. The subjects were 277 primary surgical squamous cell carcinomas with no treatment in the oral cavity, oropharynx, hypopharynx and supraglottic T_(3-4), N_(0-2) stages. Randomly divided into preoperative radiotherapy group 136 cases, postoperative radiotherapy group 141 cases. The preoperative radiotherapy group received routine external irradiation of 5000cGy/5 to 5.5 weeks and 4 to 6 weeks after radiotherapy. The postoperative radiotherapy group received surgery, and after 4 weeks, routine external irradiation of 6000cGy/6 to 7 weeks was performed. The two groups had the same surgery and resection range. The endpoints of the study were regional-local control rates, survival rates, causes of death, and treatment complications. All patients were followed up for 7 to 15 years. The main cause of death in the first 2 years after radiotherapy was regional-local failure. Two