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目的探讨原位再生复原技术(MEBT/ MEBO)治疗糖尿病患者肛周组织泛发性溃烂缺损的临床疗效.方法选择2008年11月至2011年12月收治的糖尿病型肛周脓肿导致的肛周组织泛发性溃烂缺损患者11例,全程应用原位再生复原技术与湿润烧伤膏(MEBO)治疗,临床观察其愈后外观,肛门排便功能及愈合时间等.结果11例患者全部治愈,缺损部位平均愈合时间为66.42 d ±11.41 d.治愈患者外观及功能恢复良好,达到了原位再生复原的目的.结论由糖尿病导致的肛周组织泛发性溃烂缺损,在控制原发病的同时应用原位再生复原技术治疗,均可达到原位再生复原的目的,恢复良好的外观与功能.“,”Objective To explore the clinical effect of the in situ regenerative restoration technology (MEBT/MEBO) in the treatment of generalized diabetic ulcerative defect of perianal tissue. Methods Eleven patients with the gen-eralized ulcerative defect of perianal tissue caused by diabetic perianal abscess and admitted into our department between November 2008 and December 2011 were treated with MEBT/ MEBO through the whole treatment course. The wound ap-pearance after healing, the anal defecation function and the healing time were observed. Results All the eleven patients were cured and the mean healing time of the defect sites were 66. 42 d ± 11. 41 d. The appearance of wounds after healing and the function of defect sites were well recovered, and the aim of in situ regenerative restoration was realized. Conclusion The generalized ulcerative defect of perianal tissue caused by diabetes when treated with MEBT/ MEBO at the meantime of controlling the protopathy, can realize in situ regenerative restoration with good recovery of appearance and functions.