二十多年前,Axelrod最先认为,不同种属的动物具有一种以上的肝脏微粒体药物代谢酶.后来,其他学者又观察到,不仅不同种属动物的药物代谢酶可互不相同,而且同一种属的动物,其肝脏内也含有几种酶来催化同一反应。以后,对药物代谢酶的研究,就主要集中于肝脏微粒体的血红素蛋 More than two decades ago, Axelrod first considered that animals of different species have more than one kind of liver microsomal drug metabolizing enzyme Later, other scholars also observed that not only different species of animal drug metabolizing enzymes can be different from each other, And the same species of animal, the liver also contains several enzymes to catalyze the same reaction. Later, the study of drug metabolizing enzymes, the main focus on liver microsome heme egg