63例患葡萄球菌败血症的足月新生儿在常规抗感染治疗疗效不佳时，接受国产盐酸去甲万古霉素治疗。首量15mg／kg，静脉滴注，继之10mg／kg维持治疗。结果：其血药浓度可达到20～40μg／ml的有效水平，治愈率达90．5％。用药不超过2周未见严重耳、肾毒性。结果表明：只要合理用药，去甲万古霉素在新生儿重症葡萄球菌感染的治疗中是安全有效的。 Sixty-three full-term newborns with staphylococcal septicemia were treated with domestic norvancomycin during routine anti-infective therapy. The first volume of 15mg / kg, intravenous infusion, followed by 10mg / kg maintenance treatment. Results: The plasma concentration of 20 ~ 40μg / ml effective level, the cure rate was 90.5%. No more than 2 weeks medication no serious ear, nephrotoxicity. The results show that: as long as reasonable medication, norvancomycin in the treatment of neonatal Staphylococcus aureus is safe and effective.