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[目的]研究8 羟基鸟嘌呤糖苷酶基因 (hOGG1)型、生活习惯及其相互作用与食管癌、胃癌易感性的关系。[方法]在上消化道癌高发区淮安市进行了一个病例—对照研究(食管癌93例,胃癌107例 ,人群对照200例),调查研究对象的生活习惯 ,以PCR SSCP方法分析hOGG1基因型。[结果]对照组与食管癌组、胃癌组之间的hOGG1基因型频度分布差异无显著意义。在携带hOGG1Ser326Cys或Cys326Cys基因型者中 ,吸烟显著增加食管癌、胃癌发生的危险性。饮茶习惯能降低食管癌、胃癌发生的危险性 ,这种作用在hOGG1Ser326Ser基因型携带者中更明显。[结论]在不同hOGG1基因型携带者中 ,生活习惯与食管癌、胃癌发生的关系有所不同。这些结果表明 ,食管癌、胃癌的发生与生活习惯、hOGG1基因型以及它们的相互作用有关。
[Objective] To study the relationship between the 8 oxoguanine glycosylase gene (hOGG1) type, living habits and their interactions, and the susceptibility to esophageal cancer and gastric cancer. [Methods] A case-control study (93 cases of esophageal cancer, 107 cases of gastric cancer, and 200 cases of population control) was performed in Huai’an City, a high incidence area of upper gastrointestinal cancer. The living habits of the subjects were investigated and the hOGG1 genotype was analyzed by PCR SSCP. . [Results] There was no significant difference in the frequency distribution of hOGG1 genotype between control group, esophageal cancer group and gastric cancer group. Among those who carried hOGG1Ser326Cys or Cys326Cys genotypes, smoking significantly increased the risk of developing esophageal and gastric cancers. Tea drinking habits can reduce the risk of developing esophageal and gastric cancers. This effect is more pronounced in the hOGG1Ser326Ser genotype carriers. [Conclusion] Among different hOGG1 genotype carriers, the relationship between living habits and the occurrence of esophageal cancer and gastric cancer is different. These results indicate that the occurrence of esophageal cancer and gastric cancer is related to the lifestyle, hOGG1 genotype, and their interactions.