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目的探究气道正压通气联合信必可都保治疗阻塞性睡眠呼吸暂停合并慢性阻塞性肺疾病(慢阻肺)的临床效果。方法 52例阻塞性睡眠呼吸暂停合并慢阻肺患者,随机分成观察组和对照组,各26例。观察组给予信必可都保联合气道正压通气治疗,对照组给予气道正压通气治疗。对比两组临床疗效。结果治疗后,观察组和对照组临床症状好转率分别为80.77%(21/26)、23.08%(6/26),比较差异具有统计学意义(P<0.05)。治疗后,观察组、对照组第一秒用力呼气容积与用力肺活量比值(FEV1%)、6 min步行距离分别为(41.79±10.31)%、(160.13±11.27)m和(32.46±10.25)%、(136.57±20.39)m,比较差异具有统计学意义(P<0.05)。结论阻塞性睡眠呼吸暂停合并慢阻肺,经气道正压通气、信必可都保联合治疗,临床效果较佳,值得临床深入推广。
Objective To investigate the clinical effects of positive airway pressure ventilation combined with Xinbikudubao on obstructive sleep apnea and chronic obstructive pulmonary disease (COPD). Methods Fifty-two patients with obstructive sleep apnea and chronic obstructive pulmonary disease were randomly divided into observation group and control group, with 26 cases in each group. The observation group was given Xinbifurubao combined with positive airway pressure treatment, while the control group was given positive airway pressure treatment. Compare two groups clinical curative effect. Results After treatment, the improvement rates of clinical symptoms in observation group and control group were 80.77% (21/26) and 23.08% (6/26), respectively. The difference was statistically significant (P <0.05). After treatment, the forced expiratory volume and forced vital capacity (FEV1%) and the walking distance of 6 min in observation group and control group were (41.79 ± 10.31)%, (160.13 ± 11.27) m and (32.46 ± 10.25)%, respectively , (136.57 ± 20.39) m, the difference was statistically significant (P <0.05). Conclusions Obstructive sleep apnea with COPD, combined with positive airway pressure and Xinbikuduo combination therapy have better clinical effect and deserve clinical promotion.