目的探究小于胎龄儿(SGA)宫外生长发育迟缓(EUGR)与血浆游离肉碱(FC)水平的相关性。方法选择2013年1~12月在佛山市妇幼保健院出生的SGA 113例为实验组,根据出生体重(BW)划分为A组(BW≤1 500 g)及B组(BW>1 500 g),测量并根据其生后第28天的体重,分为EUGR A组51例,非EUGR A组15例,EUGR B组33例,非EUGR B组14例。另选取同时期在该院出生的正常足月儿(37周≤胎龄<42周)20例作为对照组。应用串联质谱分析仪检测所有对象生后6 h内及第7天、14天、21天、28天血浆FC水平。结果以体重为标准,实验组EUGR发生率为74.3%(84/113),各组FC随时间变化呈先下降后上升的趋势。对照组FC在第7天降为最低,下降幅度为24%,A组在第14天降为最低,下降幅度为44%(EUGR)及45%(非EUGR),B组在第14天已呈上升趋势,下降幅度为38%(EUGR)及32%(非EUGR)。对照组在28天时超过出生时水平,实验各组在28天时均未恢复到出生时水平。EUGR组FC值均明显低于同体重级别非EUGR组(P<0.05)。结论 SGA宫外生长发育迟缓发生率较高,其血浆FC值明显低于同组宫外生长发育正常儿,且FC下降持续的时间及幅度可能在这一过程中起重要作用。 Objective To investigate the correlation between euglycemic growth retardation (EUGR) and plasma free carnitine (FC) in infants of small gestational age (SGA). Methods One hundred and thirteen SGA patients born in Foshan MCH from January 2013 to December 2013 were selected as experimental group and divided into group A (BW≤1,500 g) and group B (BW> 1,500 g) according to birth weight (BW) , Were measured and divided into 51 cases of EUGR A group, 15 cases of non-EUGR A group, 33 cases of EUGR B group and 14 cases of non-EUGR B group according to the weight of their 28th day after birth. Another 20 cases of normal full-term infants (37 weeks