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目的研究动脉硬化患者颈动脉斑块与血浆纤溶活性的关系。方法对动脉硬化患者行颈动脉彩超检查,分为颈动脉内膜增厚、硬斑、混合斑、软斑四组,分别测定血浆组织型纤溶酶原激活物(tPA)与纤溶酶原激活物抑制剂(PAI)活性。结果不同类型颈动脉斑块血浆纤溶活性比较无显著性差异(P>0.05);tPA与颈动脉IMT及斑快crouse积分之间均无相关性;PAI与颈动脉IMT及斑快crouse积分之间呈直线相关关系。结论动脉硬化患者颈动脉斑块与血浆纤溶活性有相关性。
Objective To study the relationship between carotid artery plaque and plasma fibrinolysis activity in patients with atherosclerosis. Methods Carotid ultrasonography was performed in patients with atherosclerosis. The carotid artery was divided into four groups: carotid intima-media thickness, plaque, mixed plaque and soft spot. Tissue plasminogen activator (tPA) and plasminogen Activator inhibitor (PAI) activity. Results There was no significant difference in plasma fibrinolytic activity between different types of carotid plaques (P> 0.05). There was no correlation between tPA and carotid artery IMT and plaque crouse score. PAI and carotid IMT and plaque crouse score A linear relationship between. Conclusion There is a correlation between carotid plaques and plasma fibrinolytic activity in patients with atherosclerosis.