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目的探讨湖北省家庭内多人感染HIV的原因,为制定控制HIV家庭内传播策略提供依据。方法收集至2009年底全省有2人及以上感染HIV家庭的艾滋病病毒感染者和艾滋病病人的有关情况,进行统计分析。结果(1)全省有2人及以上患有HIV的家庭比例为16.50%,发生家庭内二代传播的家庭比例为12.31%;(2)家庭内不同的首次感染HIV方式对家庭内发生二代传播的时间间隔有影响,首次经性感染后再经性的二代传播速度明显快于首次经血感染的(t=4.247,P<0.01)和母婴传播(t=2.908,P<0.01)的方式;(3)男女配偶间HIV传播效率男性要高于女性(χ2=9.121,P<0.01);(4)家庭内首发感染者性别、年龄、文化程度对是否发生家庭二代传播没有影响(χ2=0.641或F=2.836或χ2=4.174,P均>0.05),但开展艾滋病抗逆转录病毒治疗、感染者不到外地打工或是经商可以明显减少家庭内HIV二代传播的发生(χ2=294.970或χ2=31.687,P均<0.05)。结论首次经性感染后再发生家庭内经性二代传播的传播速度明显快于首次经血感染和母婴传播的方式;男女配偶间HIV传播效率男性要高于女性;及早开展抗逆转录病毒治疗、减少感染者外出打工或经商均可有效控制家庭内HIV的二代传播。
Objective To explore the causes of multi-human infection of HIV in the family in Hubei Province and provide the basis for the development of strategies to control the spread of HIV in the home. Methods To collect and analyze the situation of HIV-infected persons and AIDS patients who had 2 or more HIV-infected families in the province by the end of 2009. Results (1) The proportion of households with two or more people living with HIV in the province was 16.50%, and the proportion of households with second-generation transmission within the family was 12.31%. (2) The first HIV infection in the family occurred in two The transmission time of the first generation was significantly faster than that of the first menstrual transmission (t = 4.247, P <0.01) and mother to infant transmission (t = 2.908, P <0.01) (3) The HIV transmission efficiency of males and females was higher than that of females (χ2 = 9.121, P <0.01); (4) The gender, age and education level of first-time inpatients had no effect on the second generation of family transmission (χ2 = 0.641 or F = 2.836 or χ2 = 4.174, all P> 0.05). However, HIV / AIDS-related anti-retroviral therapy could not reduce the incidence of HIV secondary transmission in the family = 294.970 or χ2 = 31.687, P <0.05). Conclusions The transmission rate of sexual second generation in the family after the first sexual intercourse is significantly faster than that of the first menstrual and maternal-to-infant transmission. The HIV transmission rate among males and females is higher than that of females in males and females. Early antiretroviral therapy, Reducing the number of migrant workers who go out for work or business can effectively control the second generation of HIV transmission in the family.