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采用四氯化碳致大鼠肝硬化模型，观察口服谷氨酰胺对肝硬化大鼠肝功、死亡率及空肠粘膜谷胱甘肽含量的影响，并对空、回肠粘膜进行了组织形态学观察。结果表明，谷氨酰胺对肝硬化大鼠肝功、死亡率无明显影响。与模型对照组相比，谷氨酰胺治疗组空肠粘膜谷胱甘肽含量及空、回肠粘膜厚度、绒毛高度显著增加（ Ｐ＜００５），且上述指标与正常组比较差异无显著性。表明补充外源性谷氨酰胺可明显减轻肝硬化时肠粘膜损伤，增加空肠粘膜谷胱甘肽含量。提示谷氨酰胺可用于预防肝硬化时与肠粘膜损伤有关的各种并发症的发生
CCl4 induced liver cirrhosis model was used to observe the effect of oral administration of glutamine on hepatic function and mortality of jejunal rats and jejunal mucosal glutathione content. Morphological observation of the empty and ileal mucosa . The results showed that glutamine had no significant effect on liver function and mortality in cirrhotic rats. Compared with the model control group, the glutamine treatment group, the glutathione content of jejunum mucosa and empty, ileum mucosa thickness, villus height was significantly increased (P <0 05), and the above indicators compared with the normal group no significant difference. It is indicated that supplementation of exogenous glutamine can significantly reduce the intestinal mucosal damage during cirrhosis and increase the glutathione content of jejunum mucosa. Suggesting that glutamine can be used to prevent various complications associated with intestinal mucosal injury during cirrhosis