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目的探讨滋肾活血方对156例糖尿病肾病Ⅲ期气阴两虚兼血瘀证患者血液流变学的临床观察。方法将2010年3月-2013年4月柳州市中医院156例糖尿病肾病Ⅲ期患者随机分为治疗组和对照组各78例。两组均采用饮食控制和糖尿病常规治疗。治疗组采用滋肾活血方治疗,对照组采用贝那普利片治疗,疗程12周。结果治疗组血液流变学各项指标、尿蛋白排泄率、血糖及中医症状较治疗前显著下降(P<0.05或P<0.01);与对照组比较血液流变学各项指标、尿白蛋白排泄率(UAER)、血糖、血脂及中医症状改善明显优于对照组(P<0.01或P<0.05)。结论滋肾活血方能改善糖尿病肾病Ⅲ期患者的血液流变学、血脂和微循环,减少尿白蛋白的排出,减轻肾损害,改善肾功能。
Objective To investigate the clinical effect of Zishenhuoxue decoction on the hemorheology of 156 patients with diabetic nephropathy in stage Ⅲ with deficiency of both qi and blood and blood stasis syndrome. Methods From March 2010 to April 2013, 156 patients with stage Ⅲ diabetic nephropathy in Liuzhou Traditional Chinese Medicine Hospital were randomly divided into treatment group (78 cases) and control group (78 cases). Both groups were treated with diet control and routine diabetes. The treatment group was treated with Zishenhuoxue prescription, while the control group was treated with benazepril tablets for 12 weeks. Results The indexes of hemorheology, urinary protein excretion rate, blood glucose and symptoms of TCM in the treatment group were significantly lower than those before treatment (P <0.05 or P <0.01). Compared with the control group, the indexes of hemorheology, urinary albumin UAER, blood glucose, blood lipid and TCM symptoms were significantly better than the control group (P <0.01 or P <0.05). Conclusion Zishenhuoxue can improve blood rheology, blood lipids and microcirculation in patients with stage Ⅲ diabetic nephropathy, reduce urinary albumin excretion, reduce renal damage and improve renal function.