Studies on a New Usage of Hypophosphorous Acid—iodine System in N—C Bond Cleavage

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A mixture of hypophosphorous acid (H3PO2) and iodine in acetic acid can cleave theN-alkyl bond in a variety of N-1 substituted pyrimidine derivative in relatively high yields, withoutany damage to the amido bond in the non-nucleosides pyrimidine base skel
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