目的　研究氟他胺及其活性代谢产物 2 羟基氟他胺诱导正常大鼠前列腺细胞凋亡的作用。方法　大鼠设正常组、去势组及给药组 ,比较前列腺各侧叶湿重 ,以HE染色及TUNEL染色法观察细胞凋亡并计算凋亡发生率。结果　氟他胺 10 0mg·kg-1及 2 羟基氟他胺 5 0mg·kg-1给药 7d可明显降低前列腺各侧叶湿重 ,并可观察到明显的凋亡细胞。结论　氟他胺与 2 羟基氟他胺可诱导正常大鼠前列腺细胞凋亡。 Objective To investigate the effect of flutamide and its active metabolite 2-hydroxyflutamide on the apoptosis of prostatic cells in normal rats. Methods Rats were divided into normal group, castration group and administration group. The wet weight of each side of prostate was compared. HE staining and TUNEL staining were used to observe the apoptosis rate and the incidence of apoptosis. Results Flutamide 10 mg · kg-1 and 2-hydroxyflutamide 50 mg · kg-1 administration for 7 days significantly reduced the wet weight of each side of the prostate, and significant apoptotic cells were observed. Conclusion Both flutamide and 2-hydroxyflutamide can induce apoptosis of normal rat prostate cells.