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作者收集36篇家族性多发性骨髓瘤的文献,连同本文报告的一个家族(母与子)共37篇报告。在家族中发病者大多数是兄弟姊妹,作者统计了21篇36个家族的骨髓瘤家庭中,兄弟和姊妹10个家系,兄弟间8个家系,姊妹间6个家系,母子间3个家系,患者和姑侄间3个家系,父女间2个家系,其他亲戚关系4个家系。这些患者在性别、年龄、单克隆蛋白类型的分布以及临床、实验室资料和疾病预后与非家族性骨髓瘤没有什么不同,但家族性骨髓瘤家庭亲属中发现健康成员有异常免疫球蛋白增高。关于浆细胞恶性变的原因,有作者认为有遗传倾
The authors collected 36 articles of familial multiple myeloma, together with 37 reports of one family (mother and son) reported in this article. Most of the patients in the family were brothers and sisters. Among 21 families of 36 myeloma families, the authors counted 10 pedigrees of brothers and sisters, 8 pedigrees of brothers, 6 siblings, 3 pedigrees of mother and child, There were 3 pedigrees between the patient and his nephew, 2 pedigrees between father and daughter and 4 relatives. These patients did not differ from non-familial myeloma in terms of sex, age, distribution of monoclonal protein types, and clinical, laboratory data, and disease prognosis, but abnormal immunoglobulin was found in healthy family members of familial myeloma patients. About the reason of plasma cell malignant change, the author thinks there is genetic dumping