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目的:评估安徽省宿州市艾滋病抗病毒治疗效果，分析治疗失败患者的基因型耐药情况，为调整治疗方案提供科学依据。方法:对宿州市2019年第四季度正在治疗的1 060例艾滋病患者进行随访，检测其CD4n + T淋巴细胞计数和HIV-1病毒载量（viral load，VL），并对VL>1 000 cps/mL的患者进行基因型耐药检测。n 结果:1 060例患者最近一次CD4n + T淋巴细胞计数较初始治疗前显著升高（n t=-31.014，n P1 000 cps/ml was detected.n Results:The mean CD4n + T-lymphocytes counts were significantly higher than those before the initial treatment (n t=-31.014, n P<0.001). The viral suppression rate of HIV-1 (VL1 000 cps/ml was 49.3% (33/67). The proportion of drug-resistant mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI), nucleoside reverse transcriptase inhibitor (NRTI) and protease inhibitor (PI) were 44.8% (30/67), 20.9% (14/67) and 4.5% (3/67), respectively. The sites with the highest mutation frequency were M184, K103 and V106 (all were 17.9%. 12/67). The proportion of dual drug resistant mutations to NRTI and NNRTI was 19.4% (13/67), and there was a case of multi-drug resistance mutation to PI, NRTI and NNRTI. Resistance was mainly 3TC/FTC/NVP/EFV.n Conclusions:The viral suppression rate of HIV/AIDS was high after antiretroviral treatment in Suzhou city. But drug resistance was common among patients with treatment failure and multi-resistance case was also found. It is recommended to detect timely the viral load and genotype resistance to provide a scientific basis for the adjustment of treatment plan.