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目的探讨肿瘤患者进行置入中心静脉导管后深静脉血栓发生情况及相关危险因素。方法对702例行中心静脉置管的恶性肿瘤患者，对其性别、年龄、原发疾病、置管部位、血红蛋白和D-二聚体水平与血栓发生情况进行回顾性分析。结果23例发生深静脉血栓栓塞（VTE），中心静脉置管后深静脉血栓发生与肿瘤分期、治疗及患者血液D-二聚体水平相关。结论晚期肿瘤患者中心静脉置管易发生深静脉血栓，对于有血栓高危的肿瘤患者中心静脉置管后需预防性干预。“,”Objective To investigate the risk factors of thrombosis fol owing central venous catheter (CVC) in cancer patients. Methods CVC - associated thrombosis was investigated in 702 patients receiving placement of CVC. Results There were 23 CVC-associated thrombosis among 702 patients. Patients with adanced cancer,chemotherapy,and increase of blood d-dimer were the important risk factors for CVC-associated thrombosis. Conclusion Adanced tumors fol owing central venous catheter prone to deep vein thrombosis. Patients with high risk of blood clots after central venous catheter should give preventive intervention.