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[目的]研究p16、CD44v6和nm23鄄H1在胃癌中的表达规律,综合评价它们对患者预后的意义。[方法]用免疫组织化学LSAB方法,检测p16、CD44v6和nm23鄄H1蛋白在65例胃癌手术切除标本中的表达情况,并对它们与患者生存率的关系进行单因素和多因素分析。[结果]p16和nm23鄄H1的表达与胃癌的浸润、淋巴结转移和TNM分期呈负相关,CD44v6的阳性表达率与浸润深度、淋巴结转移和TNM分期呈正相关。p16和nm23鄄H1呈正相关,和CD44v6呈负相关。单因素分析表明,p16、CD44v6和nm23鄄H1是影响患者3年生存率的因素,多因素分析表明,只有p16是影响患者生存率的独立因素。[结论]p16、CD44v6和nm23鄄H1参与了胃癌的发展过程,对胃癌的预后有重要意义,p16可能是更有价值的预后指标。
[Objective] To study the expression regularity of p16, CD44v6 and nm23-H1 in gastric cancer, and to evaluate their prognostic significance. [Methods] The expressions of p16, CD44v6 and nm23-H1 protein in 65 cases of gastric cancer surgically resected specimens were detected by immunohistochemistry LSAB method, and their relationship with the survival rate of patients were analyzed by single factor and multivariate analysis. [Results] The expressions of p16 and nm23-H1 were negatively correlated with the infiltration, lymph node metastasis and TNM stage in gastric cancer. The positive rate of CD44v6 was positively correlated with the depth of invasion, lymph node metastasis and TNM stage. p16 and nm23 Juan H1 was positively correlated, and CD44v6 was negatively correlated. Univariate analysis showed that p16, CD44v6 and nm23-H1 were the factors affecting the 3-year survival rate of patients, multivariate analysis showed that only p16 was an independent factor affecting the survival rate of patients. [Conclusion] p16, CD44v6 and nm23-H1 are involved in the development of gastric cancer and have important significance for the prognosis of gastric cancer. P16 may be a more valuable prognostic indicator.