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目的：观察抗氧化剂维生素Ｅ对慢性肾衰之残存肾组织和残肾功能的保护作用。方法：在５／６肾切除大鼠慢性肾衰模型上，以假手术大鼠为对照，采用形态计量和生化测定方法，对比分析术后３０、６０、９０、１２０ｄ给予或不给予维生素Ｅ治疗的慢性肾衰大鼠残肾纤维化程度，残肾功能及其活性氧化代谢状况等指标。结果：大鼠术后残存肾小球呈代偿性肥大、肾小球毛细血管代偿性增生的同时，有显著的氧自由基反应亢进、抗氧化能力减弱、肾小球硬化、滤过膜增厚、肾间质纤维化、肾组织羟脯氨酸含量增高、肾功能进行性恶化；而用维生素Ｅ治疗的大鼠，氧自由基反应和抗氧化能力趋于正常，肾小球硬化、滤过膜增厚、肾间质纤维化和肾组织羟脯氨酸含量增高的程度显著减轻，肾小球代偿性肥大和肾小球毛细血管代偿性增生的发生时间后移，肾功能恶化的速度显著减慢。结论：维生素Ｅ通过其抗氧化作用，显著抑制５／６肾切除所致慢性肾衰残肾组织纤维化，延缓残肾功能进行性恶化的速度，而对代偿性肾小球肥大和毛细血管增生无明显直接影响。
Objective: To observe the protective effect of antioxidant vitamin E on residual renal tissue and residual renal function in patients with chronic renal failure. Methods: The model of chronic renal failure was established in 5/6 nephrectomized rats. Sham-operated rats were used as control. Morphometric and biochemical methods were used to compare the effects of vitamin E on the 30, 60, 90 and 120 days after operation Of chronic renal failure rat residual renal fibrosis, residual renal function and activity of oxidative metabolism and other indicators. Results: The remnant glomeruli in rats showed compensatory hypertrophy and compensatory glomerular capillary hyperplasia, and at the same time, there was a marked increase of oxygen radical reaction, weakened antioxidant capacity, glomerular sclerosis and filtration membrane Thickening, renal interstitial fibrosis, renal hydroxyproline content increased, progressive deterioration of renal function; and vitamin E-treated rats, oxygen free radical reaction and antioxidant capacity to normal, glomerular sclerosis, Thickening of the filtration membrane, renal interstitial fibrosis and hydroxyproline in renal tissue increased the degree of significant reduction in glomerular compensatory hypertrophy and glomerular capillary compensatory proliferation of time after the shift, renal function The rate of deterioration slowed significantly. Conclusion: Vitamin E can significantly inhibit the renal fibrosis of chronic renal failure caused by 5/6 nephrectomy and delay the progressive worsening of residual renal function through its anti-oxidant effect. However, vitamin E can inhibit the glomerular compensatory glomerular hypertrophy and capillary No obvious direct impact on proliferation.