氯喹的抗疟作用在于它与“血结合剂”争夺高铁血红素Ⅸ;后者是膜损伤剂,能改变膜的渗透性。氯喹进入疟原虫的食物泡,损伤食物泡膜,邻近的食物泡融合并形成自噬泡,致成疟原虫的死亡。亲溶酶体的脂质体作为药物载体,将较多的氯喹带入疟原虫的食物泡内而增强其抗疟作用。本文即根据此而设计。 The anti-malarial effect of chloroquine is that it competes with “blood binders” for hematin IX; the latter is a membrane damaging agent that alters the membrane’s permeability. Chloroquine into the malaria parasite food bubble, damage the food bubble membrane, adjacent food fusion and the formation of autophagic vacuoles, resulting in the death of malaria parasite. Liposomes that are lysosomal lysosomes act as drug carriers, bringing more of the chloroquine into the malaria parasite’s food vacuoles and enhancing their anti-malarial effects. This article is based on this design.