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近年来,对注射剂中污染的微粒,不断指出其危害性,因而人们对此问题,寄予了极大的关注。一、微粒污染的一些原因 1.溶液注射剂中的微粒:盐类溶液一般可侵蚀玻璃而产生所谓的脱片。青山等对市售20％KCl注射液(20ml)和加有乳酸的复方氯化钠注射液(瓶装),用电子显微镜观察其玻璃容器的内表面,发现容器内表面已被显著腐蚀,特别是KCl注射液的更为严重,用肉眼也能检查出有微粒存在。在灭菌后就可看到玻璃已受轻度侵蚀,随着侵蚀的进行而微粒凝集,以至用肉眼也能看到。
In recent years, the particles in the injection of contaminated, continue to point out the dangers, so people have placed great concern on this issue. First, some of the reasons for particulate contamination 1. Solution Injection particles: salt solution can generally erode the glass and the so-called off. Aoyama and other commercially available 20% KCl injection (20ml) and lactic acid compound sodium chloride injection (bottled), the inner surface of the glass container was observed with an electron microscope and found that the inner surface of the container has been significantly corroded, especially KCl injection more serious, with the naked eye can detect the presence of particles. After sterilization, you can see that the glass has been mildly corroded, with the agglomeration of particles as the erosion progresses, even with the naked eye.