探明失重/模拟失重状态下骨骼肌发生萎缩的机理,寻找出预防和治疗肌萎缩的有效措施,是航天医学亟待解决的重要课题之一。研究资料表明,肌梭功能活动的改变可能与失重性肌萎缩的发生、发展有着密切的联系。本研究组多年来,围绕着模拟失重条件下大鼠比目鱼肌肌梭的结构、代谢、功能等方面发生的改变展开了一系列研究。本文对我们已取得的一些主要研究成果和相关研究作一综述,以期从模拟失重条件下肌梭改变方面来探讨失重性肌萎缩的发生机制,为制定更有效的防治失重性肌萎缩的措施提供线索和依据。 Probing the mechanism of atrophy of skeletal muscle under weightlessness / simulated weightlessness and finding out effective measures to prevent and treat muscle atrophy is one of the important topics to be solved urgently in space medicine. Research data show that changes in functional activity of muscle spindle may be associated with the occurrence and development of weightless muscle atrophy. Over the years, our group has conducted a series of studies around the structure, metabolism, function and other aspects of the soleus muscle spindles under simulated weightlessness. This review summarizes some of the main research results we have obtained and related researches in order to explore the mechanism of weightless muscle atrophy from the changes of muscle spindle under simulated weightlessness and provide a more effective measure to prevent and treat weightless muscle atrophy Clue and basis.