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目的:探讨多发伤儿童免疫功能相关性。方法:收治50例多发伤儿童作为研究对象,并按照儿童创伤评分(PTS)分为轻、中、重3组,检测发病后患儿血清T淋巴细胞亚群、免疫球蛋白及补体水平,并比较不同组免疫功能相关性。结果:多发伤患儿血清淋巴细胞免疫及体液免疫功能都有不同程度下降,且随着创伤严重程度加重,免疫功能低下越显著,重度组的IgG、IgM、C3、CD3+、CD4+、CD4+/CD8+均低于轻度组(P<0.05或P<0.01),CD8+则高于中度组(P<0.01)。结论:免疫功能低下在多发伤儿童中较为多见,与创伤严重程度存在密切的关系,可能与机体过度全身炎症反应有关。减轻炎症反应,改善免疫功能是治疗的一个重要方面。
Objective: To investigate the immune function of children with multiple trauma. Methods: Fifty children with multiple traumatic injuries were enrolled in this study. The children were divided into mild, moderate and severe groups according to Children Traumatic Scoring (PTS) score. Serum levels of T lymphocyte subsets, immunoglobulins and complement were measured after onset Compare the immune function of different groups. Results: Serum lymphocyte immunity and humoral immune function of multiple traumatic children all decreased to different extents. With the severity of trauma, the immunocompromised patients were more severe. Serum IgG, IgM, C3, CD3 +, CD4 +, CD4 + / CD8 + (P <0.05 or P <0.01), and the level of CD8 + was higher than that of the moderate group (P <0.01). Conclusion: Immunocompromised children are more common in children with multiple traumas and have a close relationship with the severity of trauma. They may be related to the systemic systemic inflammatory response. Reduce the inflammatory response, improve immune function is an important aspect of treatment.