目的：:评价i.Profiler和iTrace波前像差仪测量健康人眼波前像差的一致性，分析角膜高阶像差与瞳孔直径的相关性。方法：:系列病例研究。连续纳入健康青年受检者96例（96眼），采用i.Profiler和iTrace进行波前像差测量，参数包括2～6 mm瞳孔直径下角膜和3、5 mm瞳孔直径下全眼高阶像差，包括总高阶像差（tHOA）、球差（Zn 40）、彗差（Zn 3-1、Zn 31）和三叶草像差（Zn 3-3、Zn 33）。采用配对n t检验、Pearson相关、Bland-Altman散点图、一致性界限（95%LoA）分析2种设备测量结果的一致性。n 结果：:i.Profiler和iTrace测量角膜和全眼tHOA、Zn 40、Zn 3-1、Zn 31、Zn 3-3和Zn 33的95%LoA均小于0.1 μm，显示一致性较好。i.Profiler和iTrace在4 mm瞳孔直径下测得的角膜Zn 40分别为（0.049±0.016）μm和（0.048±0.016）μm；6 mm瞳孔直径下，角膜Zn 40分别为（0.270±0.040）μm和（0.266±0.037）μm。2～6 mm瞳孔直径下，i.Profiler测量的角膜tHOA、Zn 40、Zn 3-1、Zn 31、Zn 3-3和Zn 33与瞳孔直径呈高度相关（n r=0.960、0.916、0.978、0.970、0.982、0.984，均n P<0.05）；iTrace测量的角膜高阶像差与瞳孔直径也呈高度相关（n r=0.960、0.916、0.983、0.970、0.984、0.969，均n P<0.05）。3 mm和5 mm瞳孔直径下，i.Profiler测量的全眼Zn 40分别为（0.010±0.008）μm和（0.073±0.052）μm，角膜Zn 40分别为（0.016±0.007）μm和（0.116±0.031）μm，同一瞳孔直径下，全眼Zn 40小于角膜Zn 40。n 结论：:i.Profiler和iTrace测量角膜和全眼高阶像差值具有良好一致性，二者的高阶像差测量值方面可以相互参考。“,”Objective::To evaluate the agreement between the i.Profiler and iTrace aberrometers for measuring wavefront aberrations in healthy young eyes and the correlation between corneal aberration and pupil diameter.Methods::Ninety-six healthy young eyes of 96 healthy young persons were examined by the i.Profiler and iTrace in this diagnostic test study. Corneal (2-6 mm pupil diameter) and ocular (3 mm and 5 mm pupil diameters) higher-order aberrations, including total higher-order aberrations (tHOA), fourth order (Zn 40) spherical aberration (SA), vertical coma (Zn 3-1), horizontal coma (Zn 31), vertical trefoil (Zn 3-3), and horizontal trefoil (Zn 33), were measured. Agreement between the two aberrometers was evaluated by a n t-test, Pearson correlation, Bland-Altman and 95% limits of agreement (95%LoA).n Results::The 95%LoA of the higher-order aberrations measured by i.Profiler and iTrace were relatively narrow, showing good agreement. At a 4 mm pupil diameter, corneal Zn 40 measured by i.Profiler and iTrace were 0.049±0.016 μm and 0.048±0.016 μm, respectively. At a 6 mm pupil diameter, corneal Z n 40 were 0.270±0.040 μm and 0.266±0.037 μm, respectively. At a 2-6 mm pupil diameter, corneal tHOA, SA (Z n 40), (Zn 3-1), (Zn 31), (Z3n -3) and (Zn 33) increased with an increase in pupil diameter. The corresponding correlation coefficients between corneal higher-order aberrations and pupil diameter were 0.960, 0.916, 0.978, 0.970, 0.982 and 0.984 when using i.Profiler (all n P<0.05), and the counterparts were 0.960, 0.916, 0.983, 0.970, 0.984 and 0.969 when using iTrace (alln P<0.05). At 3 mm and 5 mm pupil diameters, the measured ocular Zn 40 were 0.010±0.008 μm and 0.073±0.052 μm, respectively, which were smaller than corneal Z n 40 (0.016±0.007 μm and 0.116±0.031 μm) when using i.Profiler.n Conclusions::The i.Profiler and iTrace show good agreement in measuring wavefront aberrations in healthy young eyes.