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目的探讨马来酸曲美布汀联合复方消化酶胶囊治疗便秘型肠易激综合征的临床效果。方法将2013年10月至2016年10月期间于我院进行治疗的120例便秘型肠易激综合征患者按照自愿原则分成实验组和对照组,每组60例患者,实验组患者给予联合药物治疗,对照组单纯采用马来酸曲美布汀治疗,一个疗程结束后,评估并比较两组患者的治疗效果。结果实验组患者腹胀、腹痛、排便分型等胃肠道症状效果改善情况显著优于对照组患者,差异具有统计学意义,P<0.05。结论马来酸曲美布汀联合复方消化酶胶囊治疗便秘型肠易激综合征临床效果显著,可以提高治疗效果,改善患者的生活质量,值得临床推广应用。
Objective To investigate the clinical efficacy of trimebutine maleate and compound digestive enzyme capsules in the treatment of constipation-induced irritable bowel syndrome. Methods 120 patients with constipation-predominant irritable bowel syndrome who were treated in our hospital from October 2013 to October 2016 were divided into experimental group and control group according to the principle of voluntariness, with 60 patients in each group. Patients in experimental group were given combination drugs The control group was treated with trimebutine maleate alone. After a course of treatment, the therapeutic effects of both groups were evaluated and compared. Results The improvement of gastrointestinal symptoms such as abdominal distension, abdominal pain and defecation type in the experimental group was significantly better than that of the control group (P <0.05). Conclusion Trimebutine maleate combined with compound digestive enzyme capsules in the treatment of constipation-prone irritable bowel syndrome has a significant clinical effect, which can improve the therapeutic effect and improve the quality of life of patients, worthy of clinical application.