Objective:To investigate the effects of drug-containing serum of Chinese herbal compound, Xiongshao Capsule(芎芍胶囊,XS,for activating-blood) and Huanglian Capsule(黄连胶囊,HL,for dispellingtoxin) on the oxidized low-density lipoprotein(ox-LDL)-induced inflammatory factors in human umbilical vein endothelial cells(HUVECs).Methods:Thirty-two rats were randomly divided into four groups:the blank control group treated with distilled water,the positive control group treated with simvastatin(1.8 mg/kg),the test group I treated with Chinese herbal compound of XS(0.135 g/kg),and the test group II treated with Chinese herbal compound of XS(0.135 g/kg) and HL(0.135 g/kg).All the treatments were administered for 7 successive days by gastrogavage.Rats’ blood serum was harvested 1 h after the last administration to prepare respective drugcontaining serum.HUVECs were exposed to ox-LDL(100μg/mL) to induce cell injury model and incubated with corresponding drug-containing serum for 24 h.Untreated HUVECs were set for blank control.Levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and soluble intercellular adhesion molecule-1(slCAM-1) in supernatant of cultured HUVECs were determined by enzyme-linked immunosorbent assay(ELISA).HUVEC surface expressions of ICAM-1 and E-selectin were determined by flow cytometry.Results:Levels of IL-6, TNF-α,and slCAM-1 in the supernatant of HUVECs as well as the cell surface expressions of ICAM-1 and E-selectin significantly increased after 24-h ox-LDL stimulation(P<0.01),while the abnormal elevations,except slCAM-1 in the test groupⅠ,were all reduced in the treated groups(the positive control and the two test groups) significantly(P<0.01 or P<0.05).Besides,the effect in the test group II seemed somewhat higher than that in the test group I but with no statistical significance(P>0.05).Conclusion:Drug-containing serum of XS plus HL has a certain inhibitory effect on the vascular endothelial inflammation response induced by ox-LDL. Objective: To investigate the effects of drug-containing serum of Chinese herbal compound, Xiongshao Capsule and Huanglian Capsule (HL, for dispelling toxin) on the oxidized low-density lipoprotein ox-LDL) -induced inflammatory factors in human umbilical vein endothelial cells (HUVECs). Methods: Thirty-two rats were randomly divided into four groups: the blank control group treated with distilled water, the positive control group treated with simvastatin / kg), the test group I treated with Chinese herbal compound of XS (0.135 g / kg), and the test group II treated with Chinese herbal compound of XS (0.135 g / kg) and HL (0.135 g / kg) the treatments were administered for seven successive days by gastrogavage. Rats’ blood serum was harvested for 1 h after the last administration to prepare each drugcontaining serum. HUVECs were exposed to ox-LDL (100 μg / mL) drug-containing serum for 24 h.Untr elated HUVECs were set for blank control. Levels of interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), and soluble intercellular adhesion molecule- 1 (slCAM- 1) in supernatant of cultured HUVECs were determined by Results: Levels of IL-6, TNF-α, and slCAM-1 in the supernatant of HUVECs as well as the cell surface expressions of ICAM-1 and E-selectin significantly increased after 24-h ox-LDL stimulation (P <0.01), while the abnormal elevations except for slCAM-1 in the test group I, were all reduced in the treated groups the positive control and the two test groups were significantly (P <0.01 or P <0.05) .Besides, the effect in the test group II seemed somewhat higher than that in the test group I but with no statistical significance (P> 0.05). Conclusion: Drug-containing serum of XS plus HL has a certain inhibitory effect on the vascular endothelial response response by ox- LDL.