尽管使用了抗菌素治疗,但是细菌性败血病休克病人的死亡率仍较高。细菌内毒素被认为是导致这种休克的直接原因。所有这些败血病休克的症状都是由内毒素诱发自身细胞因子发生作用的结果。由于白细胞介素-1(IL-1)能引起心动过快和血压过低并且与肿瘤坏死因子协同造成组织的损伤和坏死,所以IL-1是败血病休克发生的一个重要因素。为深入探讨IL-1与败血病休克的关系,作者利用新发现的IL-1受体拮抗 Despite the use of antibiotic therapy, the mortality of patients with bacterial septicemia shock is still high. Bacterial endotoxins are thought to be the direct cause of this shock. All of these symptoms of septicemia are the result of endotoxin-induced autocrine effects. IL-1 is an important factor in the development of septicemia due to interleukin-1 (IL-1) can cause tachycardia and hypotension and tissue damage and necrosis in conjunction with tumor necrosis factor. To further explore the relationship between IL-1 and septic shock, the authors use the newly discovered IL-1 receptor antagonist