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[目的]探讨盐酸曲美他嗪联合不同他汀类药物对伴有高血压的心衰患者心功能影响.[方法]选择2015年9月至2017年4月在本院诊断为伴有高血压的心衰患者120例作为研究对象,采用盲选法随机分为 A组、B组和C组,每组各40例.A、B、C三组均给予常规基础治疗,并口服盐酸曲美他嗪片20 mg,3次/天;在此基础上,A、B、C组分别口服氟伐他汀、辛伐他汀、阿托伐他汀各20 mg,1次/天.治疗6个月后,比较三组疗效;治疗前及治疗6个月后,采用超声诊断仪测量并计算左心室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD),采用标准台式水银柱血压计测量收缩压(SBP)、舒张压(DBP);全自动生化分析仪上测定血脂水平包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C);并分析药物安全性.[结果]三组疗效经秩和检验发现有统计学意义(P0.05).[结论]盐酸曲美他嗪联合他汀类药物治疗伴有高血压心力衰竭均有临床效果,但联合阿托伐他汀能显著改善心功能,降低血脂水平,且疗效显著,安全性最高.“,”[Objective]To observe the effects of tricetaxine hydrochloride combined with different statins on car-diac function of heart failure with hypertension patients.[Methods]A total of 120 patients with heart failure who were treated with hypertension from August 2015 to March 2017 were randomly divided into the group A,the group B and the group C,with 40 patients of each group.The three groups were given conventional basic treatment,and o-ral tricamalt hydrochloride tablets 20mg,3 times one day,and the A group,the B group and the C group were re-spectively given oral fluvastatin,simvastatin,and atorvastatin 20mg,1 time one day.After 6 months of treatment, the efficacy of the three groups were compared;the left ventricular ejection fraction(LVEF),the left ventricular end diastolic diameter (LVEDD),and the left ventricular end-diastolic diameter(LVESD),and the left ventricular end-di-astolic diameter (LVEDD)were detected by ultrasonic diagnostic apparatus;the systolic blood pressure (SBP)and the diastolic blood pressure (DBP)were measured by a standard pool mercury sphygmomanometer;the total choles-terol (TC),the triglyceride (TG),the low density lipoprotein cholesterol (LDL-C)and the high density lipoprotein cholesterol (HDL-C)were measured by automatic biochemical analyzer;and drug safety analyze.[Results]The re-sults of rank sum test showed that there was significant difference between the three groups (P 0.05).[Conclusion]Trimetazidine hydrochloride combined with statins is effective in the treatment of hypertensive heart failure.However,its combination with atorvastatin can significantly improve cardiac function and blood lipid level,and has the highest efficacy and safety.