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维生素D_3的代谢产物1α,25(OH)_2 D_3是调节Ca~(++)代谢的激素.进一步又发现它不仅在抑制一些肿瘤细胞,如人乳癌细胞株(MCF-7 T47D)、骨髓性白血病细胞株(HL-60)、恶性黑色素瘤、大鼠成骨肉瘤等生长,延长荷瘤动物生命方面起作用,而且人未激活的单核细胞-巨噬细胞、激活的T细胞和B细胞上也存在1α,25(OH)_2D_3的受体.后者可能意味着维生素D_3还有免疫调节作用.作者通过PHA淋巴细胞转
The metabolite of vitamin D 3, 1α,25(OH)_2D_3, is a hormone that regulates Ca ++ metabolism. Furthermore, it has been found that it not only inhibits some tumor cells, such as human breast cancer cell line (MCF-7 T47D), myeloid The growth of leukemic cell lines (HL-60), malignant melanoma, rat osteogenic sarcoma, etc., contributes to prolonging the life of tumor-bearing animals, and humans do not activate monocyte-macrophages, activated T cells, and B cells. There are also receptors for 1α,25(OH)_2D_3. The latter may mean that vitamin D3 also has immunomodulatory effects. The authors have switched to PHA lymphocytes.