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目的 :对丽珠胃三联 +组胺 2受体阻制剂 (H2RA)、LOSEC +丽珠胃三联及丽珠胃三联疗法的疗效、1周疗法与 2周疗法的疗效作一探讨。方法 :经胃镜确诊的HP阳性胃溃疡、十二指肠溃疡及慢性胃炎病人随机分为 6组 ,分别予LOSEC 2 0mg ,2次 /d +丽珠胃三联 4片 2次 /d ,1周和 2周 ;泰胃美 40 0mg ,2次 /d +丽珠胃三联 4片 ,2次 /d 1周和 2周 ;丽珠胃三联 4片 ,2次 /d 1周和 2周治疗。疗程结束 4周后溃疡患者由胃镜复查 ,慢性胃炎病人由C1 3-异素呼气试验复查HP。结果 :1 50例HP阳性病人 ,总根除率为 88% ,各组间无显著性差异 ,P >0 .0 5 ,1周与 2周疗程之间 ,差异也无显著性意义 ,溃疡病治疗的有效率为 98.7% ,治愈率为72 .37% ,其中LOSEC +胃三联组 2周疗程组高于单用胃三联组 (P <0 .0 5) ,且高于泰胃美 +胃三联 1周组 ,P <0 .0 5 ;副作用发生率为 1 4 % ,主要有头昏、恶心、腹泻等 ,病人能耐受 ,依从性较好。结论 :胃三联、胃三联+PPI、胃三联 +泰胃美 1周疗程和 2周疗程均为根治HP的较好治疗方案 ,不依从服药可能是根治失败者的因素之一 ;胃和十二指肠溃疡病的治愈率以LOSEC +胃三联组高于胃三联组 ;药物副作用发生率较高但程度轻 ,绝大部分病人能耐受
OBJECTIVE: To investigate the curative effect of Livzon triple therapy + histamine 2 receptor antagonist (H2RA), LOSEC + Livzon triple therapy and Livzon stomach triple therapy, and to discuss the effects of 1 week therapy and 2 weeks therapy. Methods: HP positive gastric ulcer, duodenal ulcer and chronic gastritis diagnosed by gastroscope were randomly divided into 6 groups: LOSEC 20 mg, 2 times / d + liguzhu triple therapy 4 times / d for 1 week And 2 weeks; Taiweimei 40 0mg, 2 times / d + Livy stomach triple 4, 2 times / d 1 week and 2 weeks; Livzon stomach triple quadruple, 2 times / d 1 week and 2 weeks treatment. 4 weeks after the end of the course of ulcer patients review by gastroscopy, chronic gastritis patients by C1 3-heterologous exhaled breath test to review HP. Results: The total eradication rate of 1 50 cases of HP-positive patients was 88%, there was no significant difference among the groups. There was no significant difference between P> 0.05, 1 week and 2 weeks of treatment. The treatment of ulcer The effective rate was 98.7% and the cure rate was 72.37%. The LOSEC + gastric triple therapy group was higher than the triple therapy group (P <0.05) 1 week group, P <0. 05; the incidence of side effects was 14%, mainly dizziness, nausea, diarrhea, etc., the patient can tolerate better compliance. Conclusion: The triple therapy of stomach, triple therapy of stomach + PPI, triple therapy of stomach and stomach, stomach and stomach for one week and two weeks of treatment are all the better treatment options for radical HP. Non-compliance may be one of the factors of radical failure; The cure rate of inflammatory bowel disease was higher in LOSEC + gastric triple group than in triple gastric ulcer group. The incidence of drug side effects was higher but to a lesser extent, and the majority of patients were able to tolerate