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目的 推荐一个乳腺浸润性导管癌的预后指标 -癌巢的表面积密度 (Sv)。方法 根据体视学原理 ,采用模板法 ,测定癌实质体积密度 (Vv)及癌巢的表面积密度 (Sv)。结果 Vv、Sv与 5年生存有显著相关性。Sv≤ 4.4的患者中 ,89.3 %生存 5年以上 ,Sv >5 .5的患者中 ,82 .5 %死于 5年以内 ,前者为 5年生存的安全值 ,后者为危险值。判别函数Sv的正判率 89.2 6 %、灵敏度 (SE) 0 .92 5 0、特异度 (SP) 0 .82 93。结论 乳腺浸润性导管癌生长方式的体视学参数Sv可作为一个可靠的预后因素提供于临床。
Objective To recommend a prognostic indicator of breast invasive ductal carcinoma - the surface area density (Sv) of the cancer nest. Methods According to the stereological principle, using the template method to determine the cancer bulk density (Vv) and cancer nest surface area density (Sv). Results There was a significant correlation between Vv and Sv and 5-year survival. Of the patients with Sv ≤ 4.4, 89.3% survived for more than 5 years. Of the patients with Sv > 5%, 82.5 % died within 5 years. The former had a 5-year survival safety value and the latter was a dangerous value. The positive rate of the discriminant function Sv was 89.26%, the sensitivity (SE) was 0.925, and the specificity (SP) was 0.82 93. Conclusion Stereological parameters Sv of breast invasive ductal growth can be provided as a reliable prognostic factor in clinical practice.