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目的:探讨标准长方案与拮抗剂方案控制性超促排卵(COH)周期在卵巢低反应(POR)患者中的临床效果。方法:通过对POR患者行体外受精-胚胎移植(IVF-ET)的191个周期进行回顾性分析,其中GnRH-a长方案85个周期(A组),拮抗剂方案106个周期(B组),比较组间的临床资料及助孕结局。结果:A组的hCG注射日内膜厚度、获卵数、MII卵子数、可移植胚胎数、活产分娩率均高于B组,差异有统计学意义(P<0.05);A组的优质胚胎数、胚胎种植率、移植周期妊娠率均高于B组,A组的周期取消率、流产率均低于B组,但差异均无统计学意义(P>0.05)。结论:标准长方案对卵巢低反应患者有较好的治疗效果;标准长方案可提高患者获卵数、可移植胚胎数、活产分娩率。
Objective: To investigate the clinical effects of standard long-term regimen and antagonist regimen controlled ovarian hyperstimulation (COH) cycle in patients with low ovarian response (POR). METHODS: 191 cycles of in vitro fertilization-embryo transfer (IVF-ET) in POR patients were retrospectively analyzed. Among them, 85 cycles of GnRH-a long regimen (group A) and 106 cycles of antagonist regimen (group B) , Comparing the clinical data between groups and pregnancy outcomes. Results: The thickness of endometrium, the number of oocytes retrieved, the number of MII oocytes, the number of transplanted embryos and the live birth rate in group A were higher than those in group B on the day of hCG injection, the difference was statistically significant (P <0.05). The quality of group A The number of embryos, the implantation rate of embryos and the pregnancy rate of transplantation were all higher than those in group B. The cycle cancellation rate and abortion rate in group A were lower than those in group B, but the differences were not statistically significant (P> 0.05). Conclusion: The standard long-term regimen has good therapeutic effect on patients with low ovarian response. The standard long-term regimen can increase the number of oocytes retrieved, the number of transplanted embryos and the live birth rate.