研究证实表皮生长因子（ＥＧＦ）不影响培养人眼视网膜色素上皮（ＲＰＥ）细胞ｃＡＭＰ的基础水平，但促进异丙肾上腺素激活β＿２受体后诱导ｃＡＭＰ水平升高的效应，并呈量效依赖关系。ＥＧＦ对腺嘌呤核苷Ａ＿２受体激动剂ＮＥＣＡ诱导ｃＡＭＰ水平升高的效应没有明显影响。细胞增殖分析表明，ＥＧＦ刺激人眼ＲＰＥ细胞增殖，而ＤｉｂｕｔｙｒｙｌｃＡＭＰ和异丙肾上腺素抑制ＥＧＦ刺激增殖的效应。结果提示，在人眼ＲＰＥ细胞ＥＧＦ和β２受体之间存在受体间交互作用。 Studies have shown that epidermal growth factor (EGF) does not affect the basic level of cAMP in cultured human retinal pigment epithelium (RPE) cells, but promotes the effect of isoproterenol-activated beta 2 receptor induced cAMP levels and in a dose-dependent manner . EGF had no significant effect on the effect of adenosine A 2 receptor agonist NECA on the increase of cAMP level. Cell proliferation assays showed that EGF stimulated human eye RPE cell proliferation, whereas DibutyrylcAMP and isoproterenol inhibited the EGF-stimulated proliferation. The results suggest that there is an inter-receptor interaction between EGF and β2 receptors in human RPE cells.