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目的探讨小儿肺炎支原体感染相关脑梗死发病机制、临床特点等情况,通过测定IL-8、IL-18、sIL-2R为临床实践中小儿肺炎支原体相关脑梗死诊断、治疗及预后提供依据。方法将我科自2010年12月~2012年12月间收治的32例肺炎支原体感染导致脑梗死患者作为研究组,对其临床资料进行回顾性分析,并将既往文献报道该病患儿及同期医院内院内进行体检的健康志愿者情况进行比较,并对所得结果进行统计学处理。结果本组18例(56.25%)在出现CNS并发症前出现明显的呼吸系统感染症状,血清及脑脊液检查均显示IL-8、IL-18、sIL-2R水平显著提高(P<0.05);患儿经治疗病情均好转和改善。结论小儿肺炎支原体感染相关脑梗死除呼吸系统感染症状外,血清及脑脊液内IL-8、IL-18、sIL-2R水平明显升高等体征,采用阿奇霉素贯序疗法能显著改善症状获得良好疗效。
Objective To investigate the pathogenesis and clinical features of children with Mycoplasma pneumoniae infection-related cerebral infarction and to provide evidences for the diagnosis, treatment and prognosis of Mycoplasma pneumoniae-related cerebral infarction in children through clinical determination of IL-8, IL-18 and sIL-2R. Methods 32 cases of mycoplasma pneumoniae infection in our department from December 2010 to December 2012 were selected as the research group. The clinical data of the patients were retrospectively analyzed, and the previous literature reported that patients with the disease and the same period Hospital health check-up within the hospital volunteers were compared, and the results were statistically processed. Results 18 patients (56.25%) had obvious symptoms of respiratory infection before CNS complications. The levels of IL-8, IL-18 and sIL-2R were significantly increased in serum and cerebrospinal fluid (P <0.05) Treatment of children have improved and improved. Conclusion In addition to the symptoms of respiratory infection, the levels of IL-8, IL-18 and sIL-2R in serum and cerebrospinal fluid were significantly increased in children with acute cerebral infarction associated with Mycoplasma pneumoniae infection. Azithromycin sequential therapy could significantly improve the symptoms and obtain good results.