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目的:评价以克拉霉素为基础的短程(1周)三联疗法的幽门螺杆菌(HP)根除率。方法:采用随机对照临床试验。132例十二指肠球部溃疡(OU)和慢性胃炎(CG)HP阳性患者随机分为4个治疗组:OAC组、OFC组、OFA组、OMC组。OFA组,bid,疗程均为1周。治疗结束后4～8周作~(13)C-尿素呼气试验判断HP根除率的效果。结果:实际完成治疗127例,不同方案的HP根除率分别为:OAC组90.3％,OFC组90.9％,OMC组70.9％,及OFA组65.6％。结论:OAC组和OFC疗法对HP具有相当高的根除率,含克拉霉素的三联疗法OAC和OFC方案是适合我国国情的根除HP行之有效的方案。
PURPOSE: To evaluate the eradication rate of Helicobacter pylori (HP) in clarithromycin-based short-course (one week) triple therapy. Methods: Randomized controlled clinical trials. 132 cases of duodenal ulcer (OU) and chronic gastritis (CG) HP positive patients were randomly divided into four treatment groups: OAC group, OFC group, OFA group, OMC group. OFA group, bid, treatment for 1 week. After treatment for 4 ~ 8 weeks for ~ (13) C-urea breath test to determine the effect of HP eradication rate. Results: The actual completion of treatment of 127 cases, the different programs of HP eradication rates were: OAC group 90.3%, OFC group 90.9%, OMC group 70.9%, and OFA group 65.6%. Conclusion: The OAC group and OFC therapy have a very high eradication rate for HP. The triple therapy with clarithromycin OAC and OFC is an effective solution to eradicate HP in our country.