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目的了解郑州地区HPV感染现状及年龄分布情况,为宫颈癌防治及宫颈癌疫苗的临床应用提供数据支持。方法2011年3月-2014年3月对郑州大学第二附属医院妇科门诊10 511例患者的HPV DNA进行分型检测,并采用SPSS 17.0统计学软件分析,资料采用pearsion x~2检验。结果 10 511例患者中感染率为30.30%,其中高危型HPV感染率为67.89%,低危型HPV感染率为32.11%(多重感染者重复计数);HPV阳性率在20岁~30岁组和>50岁组出现2个高峰,依次为28.40%、43.78%;20岁~30岁和30岁~40岁人群总体发病率较高,常见亚型为HPV16和HPV58,而年龄在40岁~50岁和>50岁人群中常见亚型为HPV16和HPV52,差异均具有统计学意义。结论郑州地区妇女常见HPV亚型为高危型16、52、66型及低危型43型,且存在2个年龄段感染高峰。
Objective To understand the status and age distribution of HPV infection in Zhengzhou area and provide data support for the clinical application of cervical cancer prevention and treatment and cervical cancer vaccine. Methods From March 2011 to March 2014, HPV DNA of 10 511 patients from gynecology clinic of the Second Affiliated Hospital of Zhengzhou University were detected by SPSS 17.0 statistical software. The data were analyzed by pearsion x ~ 2 test. Results Among 10 511 patients, the infection rate was 30.30%. The prevalence of high-risk HPV infection was 67.89% and low-risk HPV infection was 32.11% (multiple infection count). The positive rate of HPV was between 20-30 years old > 50-year-old group had two peaks, followed by 28.40%, 43.78%; 20-year-old 30 years old and 30 to 40-year-old population higher overall incidence of common subtypes HPV16 and HPV58, while the age of 40 to 50 The common subtypes in the age group of> 50 years old were HPV16 and HPV52, the differences were statistically significant. Conclusion The common HPV subtypes of women in Zhengzhou area are high-risk type 16,52,66 and low-risk type 43, and there are two peak infection age groups.