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目的探讨强直性脊柱炎(AS)患者血清护骨素(OPG)和可溶性核因子κB受体活化因子配体(sRANKL)表达及意义。方法采用ELISA检测44例AS患者与44例正常对照组血清OPG和sRANKL的水平,分析其与AS的相关性。结果血清sRANKL水平及sRANKL/OPG比值在AS组均显著高于正常对照组(P<0.01)。有外周关节受累的AS患者血清OPG水平显著高于无外周关节受累的AS患者(P<0.01)。最佳截断点上血清sRANKL(>5.24pmol/L)诊断AS的敏感性、特异性和正确率分别为54.5%、84.1%、69.3%,而sRANKL/OPG比值(>0.63)均为75.0%。结论 OPG/RANKL系统可能参与AS的发病和外周关节受累;血清sRANKL/OPG比值可以用于AS的辅助诊断。
Objective To investigate the expression and significance of serum osteoprotegerin (OPG) and soluble nuclear factor kappa B receptor ligand (sRANKL) in patients with ankylosing spondylitis (AS). Methods The levels of serum OPG and sRANKL in 44 patients with AS and 44 normal controls were detected by ELISA, and their correlations with AS were analyzed. Results Serum sRANKL levels and sRANKL / OPG ratio in AS group were significantly higher than those in normal control group (P <0.01). Serum levels of OPG in AS patients with peripheral joint involvement were significantly higher than those in AS patients without peripheral joint involvement (P <0.01). The sensitivity, specificity and accuracy of serum sRANKL (> 5.24pmol / L) in the best cutoff point were 54.5%, 84.1% and 69.3%, respectively, while the ratios of sRANKL / OPG (> 0.63) were 75.0%. Conclusion The OPG / RANKL system may be involved in the pathogenesis of AS and peripheral joint involvement. The serum sRANKL / OPG ratio can be used for the diagnosis of AS.