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检测内胚窦瘤患者血清中甲胎蛋白（ＡＦＰ），研究ＡＦＰ值在妇癌临床的标记意义。收集２７例Ⅰ～Ⅳ期（ＦＩＧＯ）内胚窦瘤患者治疗前后的血清标本２１３份，平均７８８±３７９份。放射免疫法测定ＡＦＰ含量，采用等级分组的方法进行统计学处理。结果：肿瘤标志物ＡＦＰ对放射免疫法十分敏感，是诊断内胚窦瘤的重要依据Ｐ＜００１。彻底的手术可使ＡＦＰ值迅速转阴Ｐ＜００５，术后再转阳者，提示肿瘤复发或转移Ｐ＜００５。即使ＡＦＰ转阴的患者仍应坚持多程化疗。随访工作应坚持ＡＦＰ检查。ＡＦＰ值的上升或下降与患者体内内胚窦瘤细胞的生长与减灭有关，与病程的缓解与进展有关。
The serum alpha-fetoprotein (AFP) levels in patients with endodermal sinus tumors were measured and the significance of AFP values in the clinical diagnosis of gynecological cancer was studied. Twenty-seven serum samples from patients with stage I-IV (FIGO) endodermal sinus tumors were collected before and after treatment, with an average of 7 88 3 79 samples. AFP content was determined by radioimmunoassay and statistical analysis was performed using a hierarchical grouping method. RESULTS: The tumor marker AFP was very sensitive to radioimmunoassay and was an important basis for the diagnosis of endodermal sinus tumors P<001. Thorough surgery can make the AFP value turn negative quickly P<005, and then turn positive after surgery, suggesting tumor recurrence or metastasis P<005. Even patients with negative AFP should still adhere to multiple routes of chemotherapy. Follow-up work should adhere to AFP inspection. The increase or decrease of AFP value is related to the growth and degeneration of endodermal sac tumor cells in patients, and is related to the remission and progression of the disease course.