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目的探讨局部注射甲氨蝶呤在宫外孕行腹腔镜下输卵管开窗取胚术的作用及安全性。方法将本院50例宫外孕行腹腔镜下输卵管开窗取胚术患者随机分成两组,观察组25例术中局部注射甲氨蝶呤,对照组25例术中局部注射等量生理盐水,比较两组患者各时间点β-绒毛膜促性腺激素(β-HCG)水平的变化情况以及不良反应的发生率。结果术后1h观察组β-HCG与对照组相比具统计学差异(P<0.05),术后2h～14h观察组β-HCG与对照组相比差异具显著性(P<0.01)。术后对照组继发异位妊娠的比例远远高于观察组(P<0.01)。结论腹腔镜下输卵管开窗取胚术辅助局部注射甲氨蝶呤是一种安全、疗效理想的治疗方法,临床建议进一步推广。
Objective To investigate the role and safety of local injection of methotrexate in laparoscopic tubal ectoplasty in ectopic pregnancy. Methods 50 cases of ectopic pregnancy in our hospital laparoscopic tubal embryo implantation were randomly divided into two groups, the observation group 25 cases of intraoperative local injection of methotrexate, 25 cases of control group intraoperative injection of normal saline, compared The changes of β-HCG levels and the incidence of adverse reactions in both groups at different time points were compared. Results The level of β-HCG in the observation group at 1 hour after operation was significantly lower than that in the control group (P <0.05). The difference of β-HCG between the observation group and the control group was significant at 2h to 14h after operation (P <0.01). Postoperative control group, the proportion of secondary ectopic pregnancy is much higher than the observation group (P <0.01). Conclusion Laparoscopic salpingoidectomy assisted injection of methotrexate local injection is a safe and effective treatment, the clinical recommendations to further promote.