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抗氧化物对于生命早期过敏性疾病的治疗和预防具有重要意义,但是,在对婴儿实施干预之前,抗氧化物对过敏原-特异免疫反应的作用还需要进一步研究证实。在成人中进行研究的目的就是确定膳食抗氧化物对过敏原-特异性免疫反应敏感人群的影响。在随机对照实验中,54个过敏成人参与实验,其中36人补充包括β-胡萝卜素、维生素C、维生素E、锌、硒和大蒜抗氧化剂,其他18人补充安慰剂。在补充前和补充后分别测定抗氧化力、血清中的维生素C、维生素E、β-胡萝卜素、硒水平以及外周血的反应和一氧化氮呼出量,这些指标作为炎症反应的指标,血浆中的F2-异前列腺素水平作为氧化应激反应的测定指标。与安慰剂组相比,补充抗氧化物可显著增加血清中的维生素C、维生素E、β-胡萝卜素和硒水平。同时,与安慰剂组相比,补充抗氧化剂不改变血清抗氧化力、血浆F2-异前列腺素、一氧化氮呼出量和由补充抗氧化剂引起的免疫反应水平。研究认为,补充抗氧化剂可明显提高维生素C、维生素E、β-胡萝卜素和硒水平,但是不改变机体的免疫反应、血清抗氧化能力和血浆中F2-异前列腺素水平。
Antioxidants are important for the treatment and prevention of allergic diseases in early life. However, the effect of antioxidants on allergen-specific immune responses needs to be confirmed before further intervention in infants. The purpose of the study in adults was to determine the effect of dietary antioxidants on allergen-specific immune-responsive populations. In a randomized controlled trial of 54 allergic adults, 36 were supplemented with beta-carotene, vitamin C, vitamin E, zinc, selenium and garlic antioxidants, and 18 were supplemented with placebo. Antioxidant power, serum vitamin C, vitamin E, β-carotene, selenium levels, and peripheral blood and exhaled nitric oxide were measured before and after supplementation, respectively, and these indicators were used as an indicator of inflammatory response. F2-iso-prostaglandin levels as indicators of oxidative stress. Compared with placebo, supplemental antioxidants significantly increased serum levels of vitamin C, vitamin E, beta-carotene and selenium. At the same time, supplemental antioxidants did not alter serum antioxidant capacity, plasma F2-iso-prostaglandin, nitrous oxide exhaled and levels of immune responses induced by supplemental antioxidants compared with placebo. The study suggests that supplemental antioxidants can significantly increase vitamin C, vitamin E, β-carotene and selenium levels, but does not change the body’s immune response, serum antioxidant capacity and plasma F2-isoprostaglandine levels.