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目的:研究参芪注射液对冠脉结扎性心肌梗塞的影响。方法:注射给药。将麻醉犬开胸,分离冠状动脉左前降支第3个主要分支处并结扎之。于结扎后的不同时间点描记心脏外膜心电图,采血检测血清肌酸激酶(CK)、乳酸脱氢酶(LDH),并于实验后摘取心脏,称重后速冻,均匀切成薄片,氯化硝基四氮唑兰染色,分离梗塞区并称重。对各时间点、各例心脏表面各探测点心电图S-T段偏移绝对值的总和(∑-ST)与各时间点、各例心脏表面各探测点心电图ST段偏移≥2mm的心电图总点数(N-ST)、CK活性、LDH活性、心肌梗塞区重量占全心和心室重量的百分比进行组间t检验。结果:与模型对照组相比,各给药组∑-ST、N-ST、CK、LDH、梗塞区重量占全心及心室重量的百分比均显著降低。结论:参芪注射液具有显著抗冠脉结扎性心肌梗塞的作用,相同剂量下作用明显优于丹参注射液。
Objective: To study the effect of Shenqi Injection on coronary artery occlusion. Method: injection. Thoracotomy will be anesthetized dogs, isolated left anterior descending coronary artery branch 3 and the main ligation. Cardiac epicardial electrocardiogram was recorded at different time points after ligation. Serum creatine kinase (CK) and lactate dehydrogenase (LDH) were detected by blood sampling. Hearts were harvested after the test, and were weighed, frozen and sliced evenly. Chlorine Nitrotetrazolium staining, infarction zone separation and weighing. For each time point, the sum of the absolute value of ST segment offset (Σ-ST) and each time point of each electrocardiogram detection point of each cardiac surface in each case, the total number of electrocardiograms with ST offset of ST≥2mm N-ST), CK activity, LDH activity, myocardial infarction area weight as a percentage of total heart and ventricular weight. Results: Compared with the model control group, the percentages of Σ-ST, N-ST, CK, LDH, total infarct weight and total heart weight were significantly decreased in each group. Conclusion: Shenqi injection has significant anti-coronary ligation myocardial infarction, the role of the same dose was significantly better than Salvia injection.