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目的观察限制性液体复苏疗法对大鼠失血性休克死亡率的影响。方法将80只SD大鼠随机分成假手术对照组(A组)、不补液组(B组)、限制补液组(C组)和常规补液组(D组),通过颈动脉抽血制造急性失血性休克模型,同时通过剪尾制造活动性出血模型。之后分别对各组进行相应的补液方案治疗,在达到各组补液要求后停止补液并观察及统计6h内各组大鼠死亡情况。结果 A组大鼠死亡1只(5.0%);B组大鼠死亡率最高16只(80.0%);C组大鼠死亡率3只(15.0%)明显低于D组7只(35.0%)。各组间差异均有统计学意义(P<0.05)。结论限制性液体复苏在治疗性失血性休克上效果优于常规补液法。
Objective To observe the effect of restrictive fluid resuscitation on hemorrhagic shock mortality in rats. Methods 80 Sprague-Dawley rats were randomly divided into sham operation control group (A group), non-rehydration group (B group), rehydration group (C group) and conventional rehydration group (D group) Sexual shock model, at the same time through the tail-cut to create active bleeding model. After that, the patients in each group were treated with the corresponding rehydration regimen. After reaching the rehydration requirements of each group, they stopped rehydration and observed and counted the death of rats in each group within 6 hours. Results A group of rats died (5.0%). The mortality of group B was 16 (80.0%). The mortality of group C was 15.0%, which was significantly lower than that of group D (7 cases, 35.0% . The differences among the groups were statistically significant (P <0.05). Conclusion Restrictive fluid resuscitation is superior to conventional rehydration in the treatment of hemorrhagic shock.